MovDisordV3, Main, Exploration, bibRecord, 002B57

Striatal gray matter loss in Huntington's disease is leftward biased

Identifieur interne : 002B57 ( Main/Exploration ); précédent : 002B56; suivant : 002B58

Striatal gray matter loss in Huntington's disease is leftward biased

Auteurs : Mark Mühlau [Allemagne] ; Christian Gaser [Allemagne] ; Afra M. Wohlschl Ger [Allemagne] ; Adolf Weindl [Allemagne] ; Michael St Dtler [Allemagne] ; Michael Valet [Allemagne] ; Claus Zimmer [Allemagne] ; Jan Kassubek [Allemagne] ; Alexander Peinemann [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-06-15.

RBID : ISTEX:B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9

Descripteurs français

Pascal (Inist)
- Chorée Huntington, Morphométrie, Système nerveux pathologie, Voxel.

English descriptors

KwdEn :
- Adult, Aged, Brain (pathology), Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Corpus Striatum (pathology), Female, Functional Laterality (physiology), Humans, Huntington Disease (diagnosis), Huntington Disease (epidemiology), Huntington Disease (pathology), Huntington disease, Huntington's disease, Male, Middle Aged, Morphometry, Nerve Degeneration (epidemiology), Nerve Degeneration (pathology), Nervous system diseases, Neuropsychological Tests, Severity of Illness Index, Voxel, gray matter loss, lateralization, striatum, voxel‐based morphometry.
MESH :
- diagnosis : Cognition Disorders, Huntington Disease.
- epidemiology : Cognition Disorders, Huntington Disease, Nerve Degeneration.
- pathology : Brain, Corpus Striatum, Huntington Disease, Nerve Degeneration.
- physiology : Functional Laterality.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.

Abstract

In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/B1EC1DCFAFF7B2BF4B20BC7F227B45C3E75956E9/fulltext/pdf

DOI: 10.1002/mds.21137

Affiliations:

Le document en format XML

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<author><name sortKey="Wohlschl Ger, Afra M" sort="Wohlschl Ger, Afra M" uniqKey="Wohlschl Ger A" first="Afra M." last="Wohlschl Ger">Afra M. Wohlschl Ger</name>
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<author><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name>
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<front><div type="abstract" xml:lang="en">In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Striatal gray matter loss in Huntington's disease is leftward biased

Striatal gray matter loss in Huntington's disease is leftward biased

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.